Recent Research Progress on CircRNA in Hematological Malignancies--Review.
10.19746/j.cnki.issn.1009-2137.2023.03.047
- Author:
Xue BAI
1
;
Xiao-Feng CHEN
1
;
Zhong-Yu LI
1
;
Meng WANG
1
;
Jia-Jia LI
2
Author Information
1. Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, Anhui Province, China.
2. Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233003, Anhui Province, China. E-mail: 4119469@qq.com.
- Publication Type:Journal Article
- Keywords:
Hematological malignancies;
biomarker;
circular RNA;
drug-resistance;
prognosis
- MeSH:
Humans;
RNA, Circular;
MicroRNAs/genetics*;
Neoplasms;
Hematologic Neoplasms/genetics*;
Biomarkers
- From:
Journal of Experimental Hematology
2023;31(3):927-930
- CountryChina
- Language:Chinese
-
Abstract:
Most hematological tumors have high-grade malignancy and low cure rate, requiring new molecular markers for detection and evaluation. Circular RNAs (circRNAs) are a class of non-coding RNAs with covalently closed-loop structures, which participate in gene transcription and translation by binding to microRNAs and proteins. In recent years, with the deepening research on circRNAs, circRNAs have been found to play an important role in hematological malignancies. In this review, the latest research progress on the function and molecular mechanism of circRNAs in hematological malignancies was systematically summarized, and it was found that circRNAs may be potential new biomarkers and therapeutic targets in hematological malignancies.
