Research Progress on Risk Factors and Intervention Measures for Prolonged Thrombocytopenia after Allogeneic Hematopoietic Stem Cell Transplantation --Review.
10.19746/j.cnki.issn.1009-2137.2023.03.045
- Author:
Xi-Ru PENG
1
,
2
;
Juan CHENG
1
,
3
Author Information
1. The First Clinical Medical College of Lanzhou University
2. Lanzhou 730000, Gansu Province, China.
3. Department of Hematology, The First Hospital of Lanzhou University, Lanzhou 730000, Gansu Province, China.
- Publication Type:Journal Article
- Keywords:
intervention;
allogeneic hematopoietic stem cell transplantation;
prolonged thrombocytopenia;
risk factors
- MeSH:
Humans;
Transplantation, Homologous/adverse effects*;
Thrombocytopenia/etiology*;
Hematopoietic Stem Cell Transplantation/adverse effects*;
Blood Platelets/metabolism*;
Risk Factors;
Graft vs Host Disease/complications*;
Retrospective Studies
- From:
Journal of Experimental Hematology
2023;31(3):916-921
- CountryChina
- Language:Chinese
-
Abstract:
Prolonged thrombocytopenia (PT) is a common complication after allogeneic hematopoietic stem cell transplantation (allo-HSCT), with an incidence of about 5%-37%, which is closely related to the poor prognosis of patients. Previous studies have shown that transplantation type, CD34+ cell number, pretreatment regimen, acute graft-versus-host disease, virus infection, pre-transplantation serum ferritin level and donor specific antibodies can affect platelet implantation after transplantation. Identifying the risk factors of PT is helpful to early identify high-risk patients and take targeted preventive measures according to different risk factors to reduce the incidence of PT, reduce the risk of bleeding and improve the prognosis of patients. This article reviews the latest research progress of risk factors and intervention measures related to PT after allo-HSCT, in order to provide reference for the prevention and treatment of PT after transplantation.
