Research Progress of Carboxymethyl Chitosan-Based Haemostatic Materials and Their Haemostatic Mechanism --Review.
10.19746/j.cnki.issn.1009-2137.2023.03.044
- Author:
Kang REN
1
;
Li-Hao WU
1
;
Ling XU
2
Author Information
1. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian Province, China.
2. State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, School of Public Health, Xiamen University, Xiamen 361102, Fujian Province, China. E-mail:lingxu@xmu.edu.cn.
- Publication Type:Journal Article
- Keywords:
carboxymethyl chitosan;
chitosan;
haemostatic materials;
haemostatic mechanism
- MeSH:
Humans;
Hemostatics;
Chitosan/pharmacology*;
Hemostasis;
Blood Coagulation/physiology*;
Hemorrhage
- From:
Journal of Experimental Hematology
2023;31(3):911-915
- CountryChina
- Language:Chinese
-
Abstract:
Effective haemostatic materials can quickly control bleeding and achieve the purpose of saving patients' lives. In recent years, chitosan-based haemostatic materials have shown good haemostatic effects, but their application is limited because chitosan is almost insoluble in water. Carboxymethyl chitosan-based haemostatic materials can promote hemostasis by activating red blood cells and aggregating platelets. In addition, carboxymethyl chitosan can bind with Ca2+ to activate platelets and coagulation factors, and start endogenous coagulation pathways, which can adsorb fibrinogen in plasma to promote haemostasis. In this paper, the latest research progress of carboxymethyl chitosan-based haemostatic materials and their haemostatic mechanism were reviewed, in order to further strengthen the understanding of the haemostatic mechanism of carboxymethyl chitosan-based haemostatic materials, and provide new idea for the research and clinical application of carboxymethyl chitosan-based haemostatic materials.
