Research Progress on the Role of Tumor-Associated Macrophages in Multiple Myeloma --Review.
10.19746/j.cnki.issn.1009-2137.2023.02.041
- Author:
Ping-Ping ZHANG
1
,
2
;
Bing-Zong LI
2
;
Ying-Hua GENG
3
;
Feng ZHANG
3
;
Yan-Li YANG
4
Author Information
1. Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China
2. Department of Hematology, The Second Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu Province, China.
3. Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China.
4. Department of Hematology, The First Affiliated Hospital of Bengbu Medical College, Bengbu 233000, Anhui Province, China. E-mail: yyl19710702@163.com.
- Publication Type:Journal Article
- Keywords:
immunosuppression;
angiogenesis;
drug resistance;
multiple myeloma;
tumor-associated macrophages
- MeSH:
Humans;
Multiple Myeloma/pathology*;
Tumor-Associated Macrophages;
Macrophages/pathology*;
Cell Differentiation;
Tumor Microenvironment
- From:
Journal of Experimental Hematology
2023;31(2):589-592
- CountryChina
- Language:Chinese
-
Abstract:
Bone marrow microenvironment is a highly complex environment surrounding tumor, which plays an important role in the survival, proliferation, drug resistance and migration of multiple myeloma (MM) cells. As an important cellular component in tumor microenvironment, tumor-associated macrophages(TAM) has attracted attention due to its key role in tumor progression and drug resistance. Targeting TAM has shown potential therapeutic value in cancer treatment. In order to clarify the role of macrophages in MM progression, it is necessary to understand the differentiation of TAM and its characteristics of promoting MM. This paper reviews the research progress on how TAM is programmed in MM and the mechanism of TAM promoting tumor development and drug resistance.
