Research progress on the preparation and application of flavonoid nanocrystals.
10.3724/zdxbyxb-2023-0180
- Author:
Yiting TIAN
1
;
Zhiqun SHI
2
;
Huiping MA
3
Author Information
1. Department of Pharmacy, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Key Laboratory of the Plateau Medicine, Lanzhou 730050, China. tianyiting2019@163.com.
2. Department of Pharmacy, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Key Laboratory of the Plateau Medicine, Lanzhou 730050, China.
3. Department of Pharmacy, the 940th Hospital of Joint Logistics Support Force of Chinese People's Liberation Army, Key Laboratory of the Plateau Medicine, Lanzhou 730050, China. mahuiping2022@aliyun.com.
- Publication Type:Journal Article
- Keywords:
Drug delivery;
Flavonoids;
Nanocrystal;
Nanosuspension;
Preparation method;
Review;
Stabilizer
- MeSH:
Flavonoids/pharmacology*;
Pharmaceutical Preparations/chemistry*;
Biological Availability;
Nanoparticles/chemistry*;
Anti-Inflammatory Agents;
Particle Size
- From:
Journal of Zhejiang University. Medical sciences
2023;52(3):338-348
- CountryChina
- Language:English
-
Abstract:
Flavonoids have been reported to possess significant pharmacological activities,such as antioxidant, anti-inflammatory and anticancer effects. However, the low solubility and low bioavailability limits their clinical application. Nanocrystal technology can solve the delivery problems of flavonoids by reducing particle size, increasing the solubility of insoluble drugs and improving their bioavailability. This article summaries nanosuspension preparation methods and the stabilizers for flavonoid nanocrystals, and reviews the drug delivery routes including oral, Injection and transdermal of flavonoid nanocrystals, to provide information for further research on nanocrystal delivery system of flavonoids.
