Factors affecting nasal drug delivery and design strategies for intranasal drug delivery.
10.3724/zdxbyxb-2023-0069
- Author:
Xiaoyun HU
1
;
Xiao YUE
2
;
Chuanbin WU
2
;
Xuejuan ZHANG
3
Author Information
1. College of Pharmacy, Jinan University, Guangzhou 510632, China. huxiaoyun2003@163.com.
2. College of Pharmacy, Jinan University, Guangzhou 510632, China.
3. College of Pharmacy, Jinan University, Guangzhou 510632, China. zhangxj0223@jnu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Drug absorption mechanisms;
Efficiency of intranasal drug delivery;
Nasal drug delivery system;
Review
- MeSH:
Administration, Intranasal;
Drug Delivery Systems;
Pharmaceutical Preparations;
Drug Carriers;
Brain;
Nasal Cavity/physiology*;
Nasal Mucosa
- From:
Journal of Zhejiang University. Medical sciences
2023;52(3):328-337
- CountryChina
- Language:English
-
Abstract:
Intranasal drug delivery system is a non-invasive drug delivery route with the advantages of no first-pass effect, rapid effect and brain targeting. It is a feasible alternative to drug delivery via injection, and a potential drug delivery route for the central nervous system. However, the nasal physiological environment is complex, and the nasal delivery system requires "integration of medicine and device". Its delivery efficiency is affected by many factors such as the features and formulations of drug, delivery devices and nasal cavity physiology. Some strategies have been designed to improve the solubility, stability, membrane permeability and nasal retention time of drugs. These include the use of prodrugs, adding enzyme inhibitors and absorption enhancers to preparations, and new drug carriers, which can eventually improve the efficiency of intranasal drug delivery. This article reviews recent publications and describes the above mentioned aspects and design strategies for nasal intranasal drug delivery systems to provide insights for the development of intranasal drug delivery systems.
