Research progress in leveraging biomaterials for enhancing NK cell immunotherapy.
10.3724/zdxbyxb-2022-0728
- Author:
Yingqi TANG
1
;
Chenggen QIAN
2
Author Information
1. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, State Key Laboratory of Natural Medicines, Nanjing 210009, China. yingqi.tang@qq.com.
2. Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, State Key Laboratory of Natural Medicines, Nanjing 210009, China. cgqian@cpu.edu.cn.
- Publication Type:Journal Article
- Keywords:
Biomaterials;
Drug delivery;
Immunotherapy;
Modification;
NK cells;
Review
- MeSH:
Humans;
Biocompatible Materials/metabolism*;
Immunotherapy;
Killer Cells, Natural/metabolism*;
Immunotherapy, Adoptive;
Neoplasms/therapy*
- From:
Journal of Zhejiang University. Medical sciences
2023;52(3):267-278
- CountryChina
- Language:English
-
Abstract:
NK cell immunotherapy is a promising antitumor therapeutic modality after the development of T cell immunotherapy. Structural modification of NK cells with biomaterials may provide a precise, efficient, and low-cost strategy to enhance NK cell immunotherapy. The biomaterial modification of NK cells can be divided into two strategies: surface engineering with biomaterials and intracellular modification. The surface engineering strategies include hydrophobic interaction of lipids, receptor-ligand interaction between membrane proteins, covalent binding to amino acid residues, click reaction and electrostatic interaction. The intracellular modification strategies are based on manipulation by nanotechnology using membranous materials from various sources of NK cells (such as exosome, vesicle and cytomembranes). Finally, the biomaterials-based strategies regulate the recruitment, recognition and cytotoxicity of NK cells in the solid tumor site in situ to boost the activity of NK cells in the tumor. This article reviews the recent research progress in enhancing NK cell therapy based on biomaterial modification, to provide a reference for further researches on engineering NK cell therapy with biomaterials.
