Application of organic nanocarriers for intraocular drug delivery.
10.3724/zdxbyxb-2023-0035
- Author:
Wanwan CHANG
1
;
Jingjing SHEN
1
;
Zhuang LIU
1
;
Qian CHEN
2
Author Information
1. Institute of Functional Nano & Soft Materials, Soochow University, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Suzhou 215123, Jiangsu Province, China.
2. Institute of Functional Nano & Soft Materials, Soochow University, Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Suzhou 215123, Jiangsu Province, China. chenqian@suda.edu.cn.
- Publication Type:Journal Article
- Keywords:
Bioavailability;
Controlled release technology;
Drug delivery system;
Ocular barriers;
Organic nanocarrier;
Review
- MeSH:
Drug Carriers;
Delayed-Action Preparations;
Drug Delivery Systems;
Nanoparticles/chemistry*
- From:
Journal of Zhejiang University. Medical sciences
2023;52(3):259-266
- CountryChina
- Language:English
-
Abstract:
The application of intraocular drug delivery is usually limited due to special anatomical and physiological barriers, and the elimination mechanisms in the eye. Organic nano-drug delivery carriers exhibit excellent adhesion, permeability, targeted modification and controlled release abilities to overcome the obstacles and improve the efficiency of drug delivery and bioavailability. Solid lipid nanoparticles can entrap the active components in the lipid structure to improve the stability of drugs and reduce the production cost. Liposomes can transport hydrophobic or hydrophilic molecules, including small molecules, proteins and nucleic acids. Compared with linear macromolecules, dendrimers have a regular structure and well-defined molecular mass and size, which can precisely control the molecular shape and functional groups. Degradable polymer materials endow nano-delivery systems a variety of size, potential, morphology and other characteristics, which enable controlled release of drugs and are easy to modify with a variety of ligands and functional molecules. Organic biomimetic nanocarriers are highly optimized through evolution of natural particles, showing better biocompatibility and lower toxicity. In this article, we summarize the advantages of organic nanocarriers in overcoming multiple barriers and improving the bioavailability of drugs, and highlight the latest research progresses on the application of organic nanocarriers for treatment of ocular diseases.
