Recent research on platelet-leukocyte aggregates and their role in the pathogenesis of Kawasaki disease.
10.7499/j.issn.1008-8830.2302066
- Author:
Li-Chao GAO
1
;
Fang-Qi GONG
1
Author Information
1. Department of Cardiology, Children's Hospital, Zhejiang University School of Medicine/National Clinical Research Center for Child Health, Hangzhou 310052, China.
- Publication Type:Journal Article
- Keywords:
Antiplatelet agent;
Coronary artery ectasia;
Kawasaki disease;
Platelet-leukocyte aggregate
- MeSH:
Humans;
Mucocutaneous Lymph Node Syndrome/etiology*;
Blood Platelets;
Inflammation Mediators;
Leukocytes;
Neutrophils
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(6):587-594
- CountryChina
- Language:Chinese
-
Abstract:
Activated platelets may interact with various types of leukocytes such as monocytes, neutrophils, dendritic cells, and lymphocytes, trigger intercellular signal transduction, and thus lead to thrombosis and synthesis of massive inflammatory mediators. Elevated levels of circulating platelet-leukocyte aggregates have been found in patients with thrombotic or inflammatory diseases. This article reviews the latest research on the formation, function, and detection methods of platelet-leukocyte aggregates and their role in the onset of Kawasaki disease, so as to provide new ideas for studying the pathogenesis of Kawasaki disease.
