Recent research on the epidemiology and preventive strategies of neonatal group B Streptococcus infection in the latest decade.
10.7499/j.issn.1008-8830.2211140
- Author:
Meng-Yang GUO
1
;
Wei GAO
1
;
Lin YUAN
1
;
Kai-Hu YAO
1
Author Information
1. National Center for Children's Health/Beijing Children's Hospital, Capital Medical University/Laboratory of Microbiology, Beijing Pediatric Research Institute/Key Laboratory of Major Diseases in Children, Ministry of Education, Beijing 100045, China (, Email: com. cn).
- Publication Type:Journal Article
- Keywords:
Group B Streptococcus;
Intrapartum antibiotic prophylaxis;
Neonate;
Prevention;
Vaccine
- MeSH:
Female;
Humans;
Infant, Newborn;
Pregnancy;
Anti-Bacterial Agents/therapeutic use*;
Antibiotic Prophylaxis;
Infectious Disease Transmission, Vertical/prevention & control*;
Pregnancy Complications, Infectious/epidemiology*;
Streptococcal Infections/drug therapy*;
Streptococcus agalactiae
- From:
Chinese Journal of Contemporary Pediatrics
2023;25(5):534-540
- CountryChina
- Language:Chinese
-
Abstract:
Currently, the main strategy for preventing neonatal group B Streptococcus (GBS) infection is prenatal screening combined with intrapartum antibiotic prophylaxis, which has effectively reduced the incidence of neonatal GBS early-onset disease. However, the burden of GBS infection is still significant. The intrapartum antibiotic prophylaxis strategy has limitations such as inducing antibiotic resistance and inability to effectively prevent GBS late-onset disease. It is crucial to develop and evaluate other prevention strategies, while paying close attention to assessing penicillin allergy in pregnant women and how to prevent GBS infection in neonates with negative maternal GBS screening. In recent years, there has been some progress in GBS vaccines and related immunological research, and the use of specific vaccines is expected to significantly reduce GBS infection in neonates.
