A review of progress in B cell receptor (BCR) antigen specificity.
- Author:
Qingqun LI
1
;
Zhuoxuan YANG
1
;
Bin SHI
2
Author Information
1. Department of Clinical Laboratory, Affiliated Hospital, School of Laboratory Medicine, Zunyi Medical University, Zunyi 563000, China.
2. Department of Clinical Laboratory, Affiliated Hospital, School of Laboratory Medicine, Zunyi Medical University, Zunyi 563000, China. *Corresponding author, E-mail: shibin_superman@163.com.
- Publication Type:Journal Article
- MeSH:
Receptors, Antigen, B-Cell/metabolism*;
B-Lymphocytes/metabolism*;
Lymphocyte Activation;
High-Throughput Nucleotide Sequencing/methods*
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(7):663-670
- CountryChina
- Language:Chinese
-
Abstract:
B cell receptor (BCR) is a key molecule involved in B cell specific recognition and the binding of antigens to produce adaptive humoral immune response. Gene rearrangement and high frequency mutation during B cell differentiation are the main mechanisms of BCR diversification. The enormous diversity and unique molecular structure of BCR determine the diversity and specificity of antigen recognition, shaping complex B cell repertoire with extensive collections of antigen specificities. Therefore, BCR antigen-specific information is vital to understanding the adaptive immune characteristics of different diseases. Our ability to connect BCR repertoire and antigen specificity has been enhanced with the development of B cell related research technologies, such as single cell sorting techniques, high-throughput sequencing (HTS), linking B cell receptor to antigen specificity through sequencing (LIBRA-seq). It could help researchers to better understand humoral immune responses, identify disease pathogenesis, monitor disease progression, design vaccines, and develop therapeutic antibodies and drugs. We summarizes recent studies on antigen-specific BCR of infections, vaccinations, autoimmune diseases and cancer. By analyzing autoantibody sequences of SLE as a case, the identification of autoantigens has become potentially possible due to this characterization.
