Research updates of C1q/TNF related proteins (CTRPs) in inflammation-related diseases.
- Author:
Ziyin ZHANGSUN
1
;
Wangrui LEI
1
;
Yanqing LIU
1
;
Haoxiang XIAO
1
;
Yang YANG
2
Author Information
1. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an 710069, China.
2. Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an 710069, China. *Corresponding author, E-mail: yang200214yy@nwu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Complement C1q/metabolism*;
Tumor Necrosis Factor-alpha/metabolism*;
Inflammation/metabolism*;
Myocardial Infarction
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(7):649-655
- CountryChina
- Language:Chinese
-
Abstract:
Inflammation underlies a wide variety of physiological and pathological processes, and plays a pivotal role in controlling pathogen infection. C1q/tumor necrosis factor (TNF) related proteins (CTRPs), a newly discovered adipokine family with conservative structure and wide distribution, has attracted increasing attention. The CTRP family consists of more than 15 members which fall into the characteristic C1q domain. Increasing studies have demonstrated that CTRPs are involved in the onset and development of inflammation and metabolism as well as related diseases, including myocardial infarction, sepsis and tumors. Here, we first clarified the characteristic domains of CTRPs, and then elucidated their roles in inflammatory-related diseases. Taken together, the information presented here provides new perspectives for therapeutic strategies to improve inflammatory and metabolic abnormalities.
