Research progress of Helicobacter pylori vaccine.
- Author:
Ying ZHANG
1
;
Kexin LI
1
;
Yanna BI
1
;
Xiaoya LI
1
;
Baoen SHAN
1
;
Dailun HU
2
;
Lianmei ZHAO
3
Author Information
1. Scientific Research center, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050000, China.
2. Department of Pathogenic Biology, Hebei Medical University, Shijiazhuang 050000, China.
3. Scientific Research center, The Fourth Hospital, Hebei Medical University, Shijiazhuang 050000, China. *Corresponding author, E-mail: lianmeizhmail@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Helicobacter pylori;
Urease/genetics*;
Helicobacter Infections/prevention & control*;
Vaccines;
Membrane Proteins
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(6):564-570
- CountryChina
- Language:Chinese
-
Abstract:
Helicobacter pylori (Hp) is one of most common pathogens causing gastrointestinal disorder including gastric ulcer, duodenal ulcer and gastric cancer, etc. It has been verified as class I carcinogen by WHO. Nowadays, combination antibiotics and proton pump inhibitor are mainly used to erase Hp in clinical application. However, with the increased resistance of Hp, the vaccine against Hp might become the best strategy to eradicate Hp. Elements including urease, virulence factor, outer membrane protein, flagella, play an important role in Hp infection, colonization and reproduction. They have become potential candidate antigens in the development of Hp vaccine, as reported in previous studies. Presently, these antigens-centric vaccines have been tested in animal models. Therefore, this article reviews the studies on Hp vaccine with urease, virulence genes, outer membrane protein and flagella as their candidate antigens, in an attempt to provide insights for research in this regard.
