A Case of Pulmonary Thromboembolism Developed during Chemotherapy with Gemcitabine and Cisplatin for NonsmallCell Lung Cancer : A case report.
- Author:
Kyu Sik KIM
1
;
Jong Won CHUNG
;
Jong Pil JEONG
;
In Jae OH
;
Soo Ock KIM
;
Jun Gwang SON
;
Yu il KIM
;
Sung Chul LIM
;
Young Chul KIM
;
Kyung Ok PARK
Author Information
- Publication Type:Case Report
- Keywords: Gemcitabine; Thromboembolism; Lung cancer
- MeSH: Cisplatin*; Drug Therapy*; Dyspnea; Humans; Lung Neoplasms*; Lung*; Pulmonary Embolism*; Thromboembolism; Thrombophilia; Thrombosis; Walking
- From:Journal of Lung Cancer 2006;5(1):47-50
- CountryRepublic of Korea
- Language:Korean
- Abstract: Lung cancer patients have increased risk of thromboembolism (TE) due to various factors such as by hypercoagulability, tumor thrombosis, decrease of ambulation, and chemotherapy etc. Among these factors, chemotherapy associated TEs have been reported, although the causes and pathomechanisms of TEs were not clear. Recently, reports proposed the potential role of platelets in endothelial damage by the chemotherapeutic agents. We have experienced a case of pulmonary TE after systemic chemotherapy with gemcitabine and cisplatin. The patient complained aggravated exertional dyspnea after chemotherapy and diagnosed as pulmonary TE by computerized tomogram. After anticoagulation and interruption of the chemotherapy, improvement of exertional dyspnea and resolution of the pulmonary TE were observed
