Activation-induced cytidine deaminase (AID) involved in the regulation of B cell immune senescence.
- Author:
Jiaping XIAO
1
;
Jun LI
1
;
Xinsheng YAO
2
Author Information
1. Department of Immunology, Zunyi Medical University, Zunyi 563000, China.
2. Department of Immunology, Zunyi Medical University, Zunyi 563000, China. *Corresponding author, E-mail: immunology01@126.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Mice;
Aging/metabolism*;
B-Lymphocytes/metabolism*;
Cytidine Deaminase/metabolism*;
Somatic Hypermutation, Immunoglobulin
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(5):474-478
- CountryChina
- Language:Chinese
-
Abstract:
The humoral immune response of B cells is the key to the protection of specific immunity, and immune aging reshapes its production and function. The decreased B cell immune function is an indicator of immune senescence. The impaired humoral immune function mediated by antibody secreted by B cells leads to a decline in the response of elderly individuals to the vaccine. These people are therefore more susceptible to infection and deterioration, and have a higher incidence of tumors and metabolic diseases. Activation-induced cytidine deaminase (AID) is an enzyme that triggers immunoglobulin class conversion recombination (CSR) and somatic high frequency mutation (SHM). It decreases during immune senescence and is considered to be a biomarker of decreased B cell function in aging mice and humans. Understanding the inherent defects of B-cell immune senescence and the regulation mechanism of AID in the aging process can provide new research ideas for the susceptibility, prevention and treatment of diseases in the elderly.
