Notch signaling regulates macrophages during inflammation and infection: An update.
- Author:
Chuxi CHEN
1
;
Qiaoyuan LIU
1
;
Zhijie HUANG
1
;
Yunshan NING
2
;
Yan LI
3
Author Information
1. School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China.
2. School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China. *Corresponding authors, E-mail: nys@smu.edu.cn.
3. School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou 510515, China. *Corresponding authors, E-mail: luckyan@smu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Humans;
Signal Transduction;
Macrophages;
Cytokines/metabolism*;
Inflammation/metabolism*;
Communicable Diseases;
Receptors, Notch/metabolism*
- From:
Chinese Journal of Cellular and Molecular Immunology
2023;39(5):468-473
- CountryChina
- Language:Chinese
-
Abstract:
Macrophage as a crucial component of innate immunity, plays an important role in inflammation and infection immunity. Notch signal pathway is a highly conserved pathway, which regulates cellular fate and participates in numerous pathological processes. At present, a lot of literature has confirmed the role of Notch signaling in regulating the differentiation, activation and metabolism of macrophage during inflammation and infection. This review focuses on how Notch signaling promotes macrophage pro-inflammatory and anti-infective immune function in different inflammatory and infectious diseases. In this regulation, Notch signaling interact with TLR signaling in macrophages or inflammatory-related cytokines including IL-6, IL-12, and TNF-α. Additionally, the potential application and challenges of Notch signaling as a therapeutic target against inflammation and infectious diseases are also discussed.
