Progress of research on chromosomal mosaicism embryos.
10.3760/cma.j.cn511374-20220727-00496
- Author:
Zhixin HU
1
;
Kexin CHEN
;
Yonggang LI
;
Jiacong YAN
Author Information
1. The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan 650500, China. yan_jiacong@163.com.
- Publication Type:Journal Article
- MeSH:
Pregnancy;
Female;
Humans;
Preimplantation Diagnosis/methods*;
Mosaicism;
Aneuploidy;
Genetic Testing/methods*;
Blastocyst
- From:
Chinese Journal of Medical Genetics
2023;40(5):618-623
- CountryChina
- Language:Chinese
-
Abstract:
Chromosomal mosaicism (CM) is a common phenomenon in preimplantation genetic testing (PGT). In embryos with CM, genetic contents of trophoblastic ectodermal (TE) cells may be different from that of the inner cell mass (ICM) which will develop into the fetus. Embryos with low mosaic proportion could give rise to healthy live births after transplantation, but are accompanied with high pregnancy risks such as high abortion rate. In order to provide a more comprehensive understanding for CM embryos, this article has systematically summarized the recent progress of research on the definition, mechanism, classification, PGT techniques, self-correction mechanism, transplantation outcome and treatment principles for CM embryos.
