Progress of research on the role of Atoh1 gene in the regeneration of mammalian auditory hair cells.
10.3760/cma.j.cn511374-20220722-00488
- VernacularTitle:Atoh1基因在哺乳动物听觉毛细胞再生中的作用的研究进展
- Author:
Rongjie CUI
1
;
Shiyu ZHOU
;
Yunlong LI
Author Information
1. The Affiliated Hospital of Kunming University of Science and Technology Medical School, Kunming, Yunnan 650032, China. yunlongli.km@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Humans;
Basic Helix-Loop-Helix Transcription Factors/genetics*;
Hair Cells, Auditory/physiology*;
Transcription Factors;
Hearing Loss, Sensorineural;
Cell Differentiation;
Deafness;
Regeneration/genetics*;
Mammals
- From:
Chinese Journal of Medical Genetics
2023;40(5):614-617
- CountryChina
- Language:Chinese
-
Abstract:
Atoh1 gene encodes a helix-loop-helix transcription factor which is involved in the generation and differentiation of mammalian auditory hair cells and supporting cells, and regulation of the proliferation of cochlear cells, therefore plays an important role in the pathogenesis and recovery of sensorineural deafness. This study reviews the progress of the Atoh1 gene in hair cell regeneration, with the aim of providing a reference for the study of hair cell regeneration gene therapy for sensorineural deafness.
