Research progress of optic atrophy 1-mediated mitochondrial dynamics in skeletal system diseases.
10.7507/1002-1892.202302056
- Author:
Kaibo SUN
1
;
Yuangang WU
1
;
Yi ZENG
1
;
Mingyang LI
1
;
Limin WU
1
;
Bin SHEN
1
Author Information
1. Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
- Publication Type:Journal Article
- Keywords:
Mitochondrial quality control;
disorder of skeletal system;
mitochondrial dynamics;
optic atrophy 1
- MeSH:
Humans;
GTP Phosphohydrolases/genetics*;
Mitochondrial Dynamics;
Osteoarthritis;
Osteoporosis
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(6):758-763
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To review the research progress of mitochondrial dynamics mediated by optic atrophy 1 (OPA1) in skeletal system diseases.
METHODS:The literatures about OPA1-mediated mitochondrial dynamics in recent years were reviewed, and the bioactive ingredients and drugs for the treatment of skeletal system diseases were summarized, which provided a new idea for the treatment of osteoarthritis.
RESULTS:OPA1 is a key factor involved in mitochondrial dynamics and energetics and in maintaining the stability of the mitochondrial genome. Accumulating evidence indicates that OPA1-mediated mitochondrial dynamics plays an important role in the regulation of skeletal system diseases such as osteoarthritis, osteoporosis, and osteosarcoma.
CONCLUSION:OPA1-mediated mitochondrial dynamics provides an important theoretical basis for the prevention and treatment of skeletal system diseases.
