Advances in stem cell transplantation for traumatic spinal cord injury at different stages.
10.7507/1002-1892.202302028
- Author:
Yuanzhi JIN
1
;
Xin RONG
1
;
Hao LIU
1
Author Information
1. Department of Orthopedics, Orthopedic Research Institute, West China Hospital, Sichuan University, Chengdu Sichuan, 610041, P. R. China.
- Publication Type:Journal Article
- Keywords:
Spine cord injury;
clinical trial;
stem cell transplantation
- MeSH:
Humans;
Hematopoietic Stem Cell Transplantation;
Neurons;
Recovery of Function/physiology*;
Spinal Cord;
Spinal Cord Injuries/surgery*;
Stem Cell Transplantation
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(6):721-726
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To summarize the research progress of stem cell transplantation in treating spinal cord injury (SCI) at different stages based on the pathophysiological mechanism of SCI.
METHODS:The relevant research literature at home and abroad was extensively reviewed to explore the impact of transplantation timing on the effectiveness of stem cell transplantation in treating SCI.
RESULTS:Researchers performed different types of stem cell transplantation for subjects at different stages of SCI through different transplantation approaches. Clinical trials have proved the safety and feasibility of stem cell transplantation at acute, subacute, and chronic stages, which can alleviate inflammation at the injured site and restore the function of the damaged nerve cells. But the reliable clinical trials comparing the effectiveness of stem cell transplantation at different stages of SCI are still lacking.
CONCLUSION:Stem cell transplantation has a good prospect in treating SCI. In the future, the multi-center, large sample randomized controlled clinical trials are needed, with a focus on the long-term effectiveness of stem cell transplantation.
