Preparation and properties of a new artificial bone composite material.
10.7507/1002-1892.202211097
- Author:
Jianhua GE
1
;
Le JIA
1
;
Ke DUAN
1
;
Yang LI
1
;
Yue MA
1
;
Jiyuan YAN
1
;
Xin DUAN
2
;
Guibing WU
3
Author Information
1. Department of Bone and Joint Surgery, Affiliated Hospital of Southwest Medical University, Sichuan Provincial Laboratory of Orthopedic Implant Device R&D and Application Technology Engineering, Luzhou Sichuan, 646000, P. R. China.
2. Department of Orthopedics, West China Hospital of Sichuan University, Chengdu Sichuan, 610041, P. R. China.
3. Department of Orthopedics, Hejiang People's Hospital, Hejiang Sichuan, 646200, P. R. China.
- Publication Type:Journal Article
- Keywords:
Artificial bone composite material;
hyaluronic acid;
α-calcium sulfate hemihydrate;
β-tricalcium phosphate
- MeSH:
Calcium Phosphates;
Bone and Bones;
Phosphates
- From:
Chinese Journal of Reparative and Reconstructive Surgery
2023;37(4):488-494
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To study the preparation and properties of the hyaluronic acid (HA)/α-calcium sulfate hemihydrate (α-CSH)/β-tricalcium phosphate (β-TCP) material (hereinafter referred to as composite material).
METHODS:Firstly, the α-CSH was prepared from calcium sulfate dihydrate by hydrothermal method, and the β-TCP was prepared by wet reaction of soluble calcium salt and phosphate. Secondly, the α-CSH and β-TCP were mixed in different proportions (10∶0, 9∶1, 8∶2, 7∶3, 5∶5, and 3∶7), and then mixed with HA solutions with concentrations of 0.1%, 0.25%, 0.5%, 1.0%, and 2.0%, respectively, at a liquid-solid ratio of 0.30 and 0.35 respectively to prepare HA/α-CSH/ β-TCP composite material. The α-CSH/β-TCP composite material prepared with α-CSH, β-TCP, and deionized water was used as the control. The composite material was analyzed by scanning electron microscope, X-ray diffraction analysis, initial/final setting time, degradation, compressive strength, dispersion, injectability, and cytotoxicity.
RESULTS:The HA/α-CSH/β-TCP composite material was prepared successfully. The composite material has rough surface, densely packed irregular block particles and strip particles, and microporous structures, with the pore size mainly between 5 and 15 μm. When the content of β-TCP increased, the initial/final setting time of composite material increased, the degradation rate decreased, and the compressive strength showed a trend of first increasing and then weakening; there were significant differences between the composite materials with different α-CSH/β-TCP proportion ( P<0.05). Adding HA improved the injectable property of the composite material, and it showed an increasing trend with the increase of concentration ( P<0.05), but it has no obvious effect on the setting time of composite material ( P>0.05). The cytotoxicity level of HA/α-CSH/β-TCP composite material ranged from 0 to 1, without cytotoxicity.
CONCLUSION:The HA/α-CSH/β-TCP composite materials have good biocompatibility. Theoretically, it can meet the clinical needs of bone defect repairing, and may be a new artificial bone material with potential clinical application prospect.
