Blue Nevus Hidden within the Nevus of Ota.

Author: Xing LIU ¹ ; Hui-Ying ZHENG ¹ ; Fu-Min FANG ¹ ; He-Dan YANG ¹ ; Hui DING ¹ ; Yin YANG ¹ ; Yi-Ping GE ¹ ; Tong LIN ²
Author Information

1. Department of Cosmetic Laser Surgery, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
2. Jiangsu Key Laboratory of Molecular Biology for Skin Diseases and STIs, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing 210042, China.
Publication Type:Journal Article
Keywords: blue nevus; laser therapy; nevus of Ota
MeSH: Male; Humans; Child, Preschool; Nevus, Blue/pathology*; Nevus of Ota/therapy*; Skin/pathology*; Face; Skin Neoplasms/pathology*
From: Chinese Medical Sciences Journal 2023;38(1):70-72
CountryChina
Language:English
Abstract: A 3-year-old boy presented with bluish patch and scattered blue spots on the left side of his face. After several sessions of laser treatment, the azury patch in the periorbital area became even darker. Histopathology showed many bipolar, pigment-laden dendritic cells scattered in the papillary and upper reticular dermis. Immunohistochemically, these cells were positive for S100, SOX-10, melan-A, P16, and HMB-45. The positive rate of Ki-67 was less than 5%. Finally, the lesion was diagnosed with nevus of Ota concurrent with common blue nevus. Therefore, for cases of the nevus of Ota with poor response to laser treatment, the possible coexisting diseases should be suspected.