Animal experimental study on the effects of different levels of amputation on cardiovascular system.
10.7507/1001-5515.202211004
- Author:
Lei MIN
1
;
Wentao JIANG
1
;
Zhongyou LI
1
;
Xiao LI
1
;
Junjie DIAO
1
;
Renjing LIU
1
;
Tianxiang TAI
1
;
Taoping BAI
1
Author Information
1. Department of Mechanics & Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, P.R.China.
- Publication Type:Journal Article
- Keywords:
Amputation levels;
Animal model;
Biochemical index;
Cardiovascular system;
Pathological examination
- MeSH:
Animals;
Animal Experimentation;
Cardiovascular System;
Cardiovascular Diseases;
Hypertension;
Amputation, Surgical
- From:
Journal of Biomedical Engineering
2023;40(3):515-521
- CountryChina
- Language:Chinese
-
Abstract:
Vascular injury resulting from lower limb amputation leads to the redistribution of blood flow and changes in vascular terminal resistance, which can affect the cardiovascular system. However, there was no clear understanding of how different amputation levels affect the cardiovascular system in animal experiments. Therefore, this study established two animal models of above-knee amputation (AKA) and below-knee amputation (BKA) to explore the effects of different amputation levels on the cardiovascular system through blood and histopathological examinations. The results showed that amputation caused pathological changes in the cardiovascular system of animals, including endothelial injury, inflammation, and angiosclerosis. The degree of cardiovascular injury was higher in the AKA group than in the BKA group. This study sheds light on the internal mechanisms of amputation's impact on the cardiovascular system. Based on the amputation level of patients, the findings recommend more comprehensive and targeted monitoring after surgery and necessary interventions to prevent cardiovascular diseases.
