Progress in antitumor activity of diterpenoid alkaloids in plants of Aconitum.
10.19540/j.cnki.cjcmm.20230122.202
- Author:
Xiao-Zheng CHEN
1
;
Ju CHENG
2
;
Xiao-Yi SHI
1
;
Li-Yuan YANG
1
;
Xiao-Dong XIE
3
Author Information
1. Gansu University of Chinese Medicine Lanzhou 730000, China.
2. Institute of Genetics, School of Basic Medical Sciences, Lanzhou University Lanzhou 730000, China.
3. Gansu University of Chinese Medicine Lanzhou 730000, China Institute of Genetics, School of Basic Medical Sciences, Lanzhou University Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
Aconitum;
antitumor;
diterpenoid alkaloids
- MeSH:
Humans;
Aconitum/chemistry*;
Molecular Structure;
Alkaloids/analysis*;
Diterpenes/chemistry*;
Antineoplastic Agents/chemistry*;
Plant Roots/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(14):3765-3773
- CountryChina
- Language:Chinese
-
Abstract:
Small-molecule compounds with rich sources have diverse structures and activities. The active ingredients in traditional Chinese medicine(TCM) provide new sources for the discovery of new antitumor drugs. Aconitum plants as Chinese medicinal plants have the effects of dispelling wind, removing dampness, warming meridian, and relieving pain. They are mainly used to treat inflammation, pain, rheumatism, and tumors, improve heart function, and dilate blood vessels in clinical practice. Diterpenoid alkaloids are the main active components of Aconitum plants, including C20-, C19-, C18-diterpenoid alkaloids and bis-diterpenoid alkaloids. Stu-dies have demonstrated that diterpenoid alkaloids can effectively treat lung cancer, liver cancer, breast cancer, colon cancer and other cancers. Diterpenoid alkaloids are considered as the most promising natural compounds against cancers. In this review, we summarized the chemical structures and antitumor activities of C20-, C19-, C18-diterpenoid alkaloids and bis-diterpenoid alkaloids extracted from plants of Aconitum, aiming to provide reference for further development of diterpenoid alkaloids from Aconitum as antitumor drugs.
