Two new isoquinoline alkaloids from Corydalis hendersonii.
10.19540/j.cnki.cjcmm.20230404.201
- Author:
Xiao-Chun ZHOU
1
;
Xiao-Jing MA
1
;
Fu-Xing GE
1
;
Chang-Xin LIU
1
;
Ya-Na LIANG
1
;
Xiao-Li GAO
1
;
Xing-Yun CHAI
1
Author Information
1. Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine Beijing 102488, China.
- Publication Type:Journal Article
- Keywords:
Corydalis hendersonii;
Tibetan medicine;
anti-inflammatory;
anti-myocardial ischemia;
cardiomyocyte protection;
isoquinoline alkaloids
- MeSH:
Humans;
Corydalis/chemistry*;
Alkaloids/chemistry*;
Inflammation;
Spectrum Analysis;
Isoquinolines/pharmacology*
- From:
China Journal of Chinese Materia Medica
2023;48(13):3508-3515
- CountryChina
- Language:Chinese
-
Abstract:
Corydalis hendersonii(CH) is a Tibetan folk medicine with the functions of clearing heat, detoxifying, cooling blood, checking diarrhea, and lowering blood pressure. It is often used to treat high altitude polycythemia, vasculitis, peptic ulcer, and diarrhea. Nine compounds were separated from the ethanol extract of CH by silica gel, ODS, Sephadex LH-20 chromatography and semi-preparative HPLC. Their structures were identified as hendersine H(1),hendersine I(2), dehydrocheilanthifoline(3), protopine(4), izmirine(5), 6,7-methylenedioxy-1(2H)-isoquinolinone(6), icariside D_2(7), ethyl 4-(β-D-glucopyranosyloxy)-3-methoxybenzoate(8), 3-hydroxy-4-methoxybenzoic acid(9), respectively, by the spectroscopic data analysis and comparison with those in the literature. Among them, compounds 1 and 2 are new isoquinoline alkaloids, and compounds 7-9 are reported the first time for Corydalis. The hypoglycemic model of H9c2 cardiomyocytes and the inflammatory model of H9c2 cardiomyocytes induced by conditional supernatant were employed to determine the activities of the above compounds. The results showed that 20 μmol·L~(-1) compound 1 had a protective effect on H9c2 cardiomyocytes and 10 μmol·L~(-1) compounds 4 and 5 inhibited H9c2 cardiomyocyte inflammation induced by conditional supernatant.
