Correlation between Claudins Expression and Prognostic Factors in Prostate Cancer.
10.4111/kju.2010.51.4.239
- Author:
Kyung Won SEO
1
;
Young Kee KWON
;
Byung Hoon KIM
;
Chun Il KIM
;
Hyuk Soo CHANG
;
Mi Sun CHOE
;
Choal Hee PARK
Author Information
1. Department of Urology, Keimyung University School of Medicine, Daegu, Korea. chp@dsmc.or.kr
- Publication Type:Original Article
- Keywords:
Claudin 1;
CLDN5 protein;
Prostate-specific antigen;
Prostatic neoplasms
- MeSH:
Claudin-1;
Claudin-5;
Claudins;
Humans;
Neoplasm Grading;
Neoplasm Metastasis;
Prostate;
Prostate-Specific Antigen;
Prostatic Neoplasms;
Recurrence
- From:Korean Journal of Urology
2010;51(4):239-244
- CountryRepublic of Korea
- Language:English
-
Abstract:
PURPOSE: The purpose of this study was to evaluate the correlation between the expression of claudins and prognostic factors in patients with prostate cancer. MATERIALS AND METHODS: The subjects of this study were 48 patients who had undergone surgery for prostate cancer. The Gleason score (6 or lower, 7 or higher), prostate-specific antigen (PSA) level, T stage, biochemical recurrence, local recurrence, and distant metastasis were compared according to the expression of claudin-1 and claudin-5 in prostate cancer. RESULTS: In the group with a low expression of claudin-1, the Gleason score was 7 points or higher in 18 cases (82%) and 6 points or lower in 4 cases (18%). In the group with a high expression of claudin-1, the Gleason score was 7 points or higher in 13 cases (50%) and 6 points or lower in 13 cases (50%). Thus, the low-expression group had more cases with a Gleason score of 7 or higher (p=0.022). The group with a low expression of claudin-5 also had more cases with a Gleason score of 7 or higher (p=0.011). The mean PSA values in the groups with a low and high expression of claudin-1 were 9.6 ng/ml and 5.6 ng/ml, respectively (p=0.007). A low expression of claudin-5 was also associated with a high PSA value (p=0.002). There was no statistical difference in the expression of claudin-1 and claudin-5 by T stage, biochemical recurrence, local recurrence, or distant metastasis. CONCLUSIONS: The low expression of claudin-1, claudin-5 was associated with a Gleason score of 7 or higher and a high PSA value in prostate cancer.
