Phenolic derivatives from root bark of Schisandra sphenanthera.
10.19540/j.cnki.cjcmm.20230121.202
- Author:
Yuan-Yuan LIU
1
;
Rui LI
2
;
Hao-Nan XU
1
;
Chen-Wang LIU
1
;
Yu-Ze LI
1
;
Chong DENG
1
;
Xiao-Mei SONG
1
;
Wei WANG
1
;
Dong-Dong ZHANG
1
Author Information
1. College of Pharmacy, Shaanxi University of Chinese Medicine Xianyang 712046, China.
2. Drug Inspection, Monitoring and Evaluation Center in Yangling Demonstration Area Yangling 712100, China.
- Publication Type:Journal Article
- Keywords:
cell viability;
chemical constituent;
extraction and isolation;
root bark of Schisandra sphenanthera;
structural elucidation
- MeSH:
Schisandra;
Plant Bark;
Antiviral Agents;
Biological Assay;
Catechin;
Phenols
- From:
China Journal of Chinese Materia Medica
2023;48(12):3287-3293
- CountryChina
- Language:Chinese
-
Abstract:
This paper aimed to study the chemical constituents from the root bark of Schisandra sphenanthera. Silica, Sephadex LH-20 and RP-HPLC were used to separate and purify the 80% ethanol extract of S. sphenanthera. Eleven compounds were identified by ~1H-NMR, ~(13)C-NMR, ESI-MS, etc., which were 2-[2-hydroxy-5-(3-hydroxypropyl)-3-methoxyphenyl]-propane-1,3-diol(1), threo-7-methoxyguaiacylglycerol(2),4-O-(2-hydroxy-1-hydroxymethylethyl)-dihydroconiferylalcohol(3), morusin(4), sanggenol A(5), sanggenon I(6), sanggenon N(7), leachianone G(8),(+)-catechin(9), epicatechin(10), and 7,4'-dimethoxyisoflavone(11). Among them, compound 1 was a new compound, and compounds 2-9 were isolated from S. sphenanthera for the first time. Compounds 2-11 were subjected to cell viability assay, and the results revealed that compounds 4 and 5 had potential cytotoxicity, and compound 4 also had potential antiviral activity.
