Research progress in treatment of Sjögren's syndrome by traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20230306.601
- Author:
Xia ZHANG
1
;
Xiang-Yu LI
1
;
Xiong-Wei ZHANG
1
;
Nan ZENG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 611137, China School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
- Publication Type:Journal Article
- Keywords:
Sj9gren′s syndrome;
apoptosis;
aquaporin 5;
immunoregulation;
inflammation pathway;
oxidative stress;
traditional Chinese medicine
- MeSH:
Humans;
Sjogren's Syndrome/drug therapy*;
Medicine, Chinese Traditional;
Quality of Life;
Xerostomia;
Autoimmune Diseases
- From:
China Journal of Chinese Materia Medica
2023;48(12):3235-3245
- CountryChina
- Language:Chinese
-
Abstract:
Sj9gren's syndrome(SS) is an autoimmune disease with glandular dysfunction caused by the massive infiltration of the exocrine glands by lymphocytes. The pathogenesis of this disease is related to the chronic inflammatory response of the exocrine glands due to excessive activation of B cells and T cells. In addition to dry mouth and eyes, SS can also cause damage to other organs and systems in the human body, seriously affecting the quality of life of patients. Traditional Chinese medicine(TCM) has definite clinical efficacy in the treatment of SS as it can alleviate symptoms and regulate immune disorders without causing adverse reactions, demonstrating high safety. This paper reviews the current status of preclinical and clinical trials about the TCM treatment of SS in the past decade. TCM mainly mitigates SS symptoms such as dry mouth, dry eyes, dry skin, and joint pain and improves the prognosis and quality of life of patients by regulating the abnormally activated B cells and T cells, inhibiting the autoimmune response, restoring the balance between pro-inflammatory and anti-inflammatory cytokines, and reducing the pathological damage caused by immune complexes to exocrine glands and joints in SS patients.
