Chemical constituents from Paris rugosa rhizomes and their antimicrobial activities.
10.19540/j.cnki.cjcmm.20230122.201
- Author:
Xiao-Yan DUAN
1
;
Mei-Cen YUE
1
;
Jun YANG
1
;
Xue BAI
1
;
Ji-Feng LUO
1
;
Heng LI
1
;
Yue-Hu WANG
1
Author Information
1. Key Laboratory of Plant Resources and Biotechnology, Yunnan Key Laboratory for Wild Plant Resources,State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany,Chinese Academy of Sciences Kunming 650201, China.
- Publication Type:Journal Article
- Keywords:
Melanthiaceae;
Paris rugosa;
antimicrobial activity;
fluconazole-resistant strain of Candida albicans;
steroid saponin
- MeSH:
Anti-Bacterial Agents;
Candida albicans;
China;
Liliaceae;
Melanthiaceae;
Rhizome
- From:
China Journal of Chinese Materia Medica
2023;48(11):2981-2988
- CountryChina
- Language:Chinese
-
Abstract:
Paris rugosa(Melanthiaceae) only grows in Yunnan province of China at present, and its chemical constituents have not been systematically studied. In this study, nine compounds, including one new compound pariposide G(1) and eight known compounds of cerin(2), stigmast-4-en-3-one(3), β-ecdysone(4), ophiopogonin C'(5), methyl protogracillin(6), gracillin(7), parissaponin H(8), and parisyunnanoside G(9), were isolated and identified from the ethanol extract of P. rugosa rhizomes by column chromatography methods and semi-preparative high-performance liquid chromatography(HPLC). Compounds 1-9 were isolated from this plant for the first time. The antibacterial and antifungal activities of all the compounds were evaluated. The results showed that ophiopogonin C' had strong inhibitory effects on Candida albicans [MIC_(90)=(4.68±0.01) μmol·L~(-1)] and the fluconazole-resistant strain of C. albicans [MIC_(90)=(4.66±0.02) μmol·L~(-1)].
