Conversion of traditional Chinese medicine (TCM) into nanomedicine:application of theory of unification of medicines and excipients.
10.19540/j.cnki.cjcmm.20221129.302
- Author:
Hui-Quan HU
1
;
Guo-Wang CHENG
1
;
Yi-Feng WU
1
;
Yu-Tian ZHANG
1
;
Yi WU
1
;
Yi-Qin YANG
1
;
Ming YANG
2
;
Zhen-Feng WU
2
Author Information
1. Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China.
2. Key Laboratory of Modern Preparation of Chinese Medicine, Ministry of Education, Jiangxi University of Chinese Medicine Nanchang 330004, China State Key Laboratory of Innovation Drug and Efficient Energy-Saving Pharmaceutical Equipment, Jiangxi University of Chinese Medicine Nanchang 330004, China.
- Publication Type:Journal Article
- Keywords:
dosage form design;
drug co-delivery;
drug delivery system;
traditional Chinese medicine(TCM) preparation;
unification of medicines and excipients
- MeSH:
Medicine, Chinese Traditional;
Excipients;
Drugs, Chinese Herbal;
Nanomedicine;
Pharmaceutical Preparations
- From:
China Journal of Chinese Materia Medica
2023;48(7):1800-1807
- CountryChina
- Language:Chinese
-
Abstract:
In recent years, the use of active substances as excipients or as substitutes for other excipients in the design of modern drug delivery systems has received widespread attention, which has promoted the development of the theory of unification of medicines and excipients in the design of traditional Chinese medicine(TCM) preparations. Adopting the theory of unification of medicines and excipients to design drug delivery systems can reduce the use of excipients and thus the cost of preparations, reduce drug toxicity, increase drug solubility and biocompatibility, enhance synergistic effect, and realize targeted delivery and simultaneous delivery of multiple components. However, the research on the application of this theory in the modern drug delivery system of TCM preparations is still insufficient, with few relevant articles. In addition, the TCM active substances that can be used as the excipients remain to be catalogued. In this paper, we review the types and applications of the drug delivery systems with TCM active substances as excipients and describe their common construction methods and mechanisms, aiming to provide references for the in-depth research on the modern drug delivery systems for TCM preparations.
