Antiarrhythmic active components in traditional Chinese medicine acting on potassium channels.
10.19540/j.cnki.cjcmm.20221230.601
- Author:
Ci WANG
1
;
Ya-Wen CAO
2
;
Xuan ZHANG
1
;
Zhi-Hua YANG
1
;
Ze-Yu ZHANG
1
;
Ming-Wei LI
1
;
Xian-Liang WANG
2
;
Jing-Yuan MAO
2
Author Information
1. Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381, China National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion Tianjin 300381, China Graduate School, Tianjin University of Traditional Chinese Medicine Tianjin 301617, China.
2. Department of Cardiology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine Tianjin 300381, China National Clinical Research Center of Chinese Medicine Acupuncture and Moxibustion Tianjin 300381, China.
- Publication Type:Journal Article
- Keywords:
active components in traditional Chinese medicine;
arrhythmia;
potassium channel;
research progress
- MeSH:
Humans;
Potassium Channels;
Medicine, Chinese Traditional;
Anti-Arrhythmia Agents/therapeutic use*;
Arrhythmias, Cardiac/drug therapy*;
Heart Diseases/drug therapy*;
Ions
- From:
China Journal of Chinese Materia Medica
2023;48(7):1792-1799
- CountryChina
- Language:Chinese
-
Abstract:
Arrhythmia is an external manifestation of cardiac electrophysiological disorder. It exists in healthy people and patients with various heart diseases, which is often associated with other cardiovascular diseases. The contraction and diastole of myocardium are inseparable from the movement of ions. There are many ion channels in the membrane and organelle membrane of myocardium. The dynamic balance of myocardial ions is vital in maintaining myocardial electrical homeostasis. Potassium ion channels that have a complex variety and a wide distribution are involved in the whole process of resting potential and action potential of cardiomyocytes. Potassium ion channels play a vital role in maintaining normal electrophysiological activity of myocardium and is one of the pathogenesis of arrhythmia. Traditional Chinese medicine(TCM)has unique advantages in treating arrhythmia for its complex active components and diverse targets. A large number of TCM preparations have definite effect on treating arrhythmia-related diseases, whose antiarrhythmic mechanism may be related to the effect on potassium channel. This article mainly reviewed the relevant studies on the active components in TCM acting on different potassium channels to provide references for clinical drug use and development.
