Relationship between pyroptosis and cardiovascular diseases and traditional Chinese medicine prevention and treatment research.
10.19540/j.cnki.cjcmm.20221219.601
- Author:
Zi-Qin LEI
1
;
Fei LUAN
1
;
Ming GAO
1
;
Jing-Wen HU
1
;
Nan ZENG
1
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu 611137,China School of Pharmacy, Chengdu University of Traditional Chinese Medicine Chengdu 611137, China.
- Publication Type:Journal Article
- Keywords:
cardiovascular diseases;
characteristics;
mechanisms;
prevention;
pyroptosis;
traditional Chinese medicine(TCM)
- MeSH:
Humans;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/therapeutic use*;
Cardiovascular Diseases/prevention & control*;
Pyroptosis;
Myocardial Infarction/drug therapy*
- From:
China Journal of Chinese Materia Medica
2023;48(7):1779-1791
- CountryChina
- Language:Chinese
-
Abstract:
Pyroptosis is a programmed cell death initiated by the activation of caspases, which is involved in the development and progression of several cardiovascular diseases. The gasdermins, a protein family, are key executive proteins in the development of pyroptosis, which increase cell membrane permeability, mediate the release of inflammatory factors, and aggravate the inflammatory injury. Traditional Chinese medicine(TCM)has shown unique therapeutic advantages in cardiovascular diseases with multi-component and multi-target characteristics. Currently, the effective prevention and treatment of cardiovascular diseases based on the theory of pyroptosis become a new research hotspot in this field. Based on the theories of TCM and modern medicine, this study summarized the role of pyroptosis in cardiovascular diseases such as atherosclerosis, myocardial infarction, diabetic cardiomyopathy, hypertension, and myocarditis. The role of TCM, including active monomers, crude extracts, and compound preparations, in cardiovascular protection through the regulation of pyroptosis was also summarized, providing a theoretical basis for the clinical prevention and treatment of cardiovascular diseases by TCM.
