Research progress in role of autophagy in diabetic wound healing and traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20221219.401
- Author:
Xiao-Tao WEI
1
;
Tao LIU
2
;
Zhi-Jun HE
2
;
Jin-Peng LI
2
;
Yuan SONG
2
;
Jie CHEN
2
;
Hai-Gang WANG
3
;
Yuan-Xu HE
4
;
Wei-Wei WANG
1
;
Jing XIE
1
Author Information
1. Gansu University of Chinese Medicine Lanzhou 730000, China.
2. Gansu Provincial Hospital of Traditional Chinese Medicine Lanzhou 730000, China.
3. Second Provincial People's Hospital of Gansu Lanzhou 730000, China.
4. the Fourth Affiliated Hospital of Gansu University of Chinese Medicine Lanzhou 730000, China.
- Publication Type:Journal Article
- Keywords:
Beclin-1;
LC3;
autophagy;
diabetes;
p62;
traditional Chinese medicine;
ulcer
- MeSH:
Humans;
Ulcer/therapy*;
Medicine, Chinese Traditional;
Beclin-1;
Quality of Life;
Wound Healing;
Diabetes Complications;
Autophagy;
Diabetic Foot/drug therapy*;
Diabetes Mellitus/genetics*
- From:
China Journal of Chinese Materia Medica
2023;48(7):1724-1730
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic ulcer(DU) is a chronic and refractory ulcer which often occurs in the foot or lower limbs. It is a diabetic complication with high morbidity and mortality. The pathogenesis of DU is complex, and the therapies(such as debridement, flap transplantation, and application of antibiotics) are also complex and have long cycles. DU patients suffer from great economic and psychological pressure while enduring pain. Therefore, it is particularly important to promote rapid wound healing, reduce disability and mortality, protect limb function, and improve the quality of life of DU patients. By reviewing the relevant literatures, we have found that autophagy can remove DU wound pathogens, reduce wound inflammation, and accelerate ulcer wound healing and tissue repair. The main autophagy-related factors microtubule-binding light chain protein 3(LC3), autophagy-specific gene Beclin-1, and ubiquitin-binding protein p62 mediate autophagy. The traditional Chinese medicine(TCM) treatment of DU mitigates clinical symptoms, accelerates ulcer wound healing, reduces ulcer recurrence, and delays further deterioration of DU. Furthermore, under the guidance of syndrome differentiation and treatment and the overall concept, TCM treatment harmonizes yin and yang, ameliorates TCM syndrome, and treats underlying diseases, thereby curing DU from the root. Therefore, this article reviews the role of autophagy and major related factors LC3, Beclin-1, and p62 in the healing of DU wounds and the intervention of TCM, aiming to provide reference for the clinical treatment of DU wounds and subsequent in-depth studies.
