Strategy and challenge of innovative drug research and development from clinically effective ingredients of traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20230112.201
- Author:
Xin LUAN
1
;
Min HUANG
2
;
Bo-Wen KE
3
;
Guang-Bo GE
1
;
Wei-Dong ZHANG
4
Author Information
1. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China.
2. Shanghai Institute of Materia Medica, Chinese Academy of Science Shanghai 201203, China.
3. West China School of Medicine, Sichuan University Chengdu 610041, China.
4. Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China School of Pharmacy, Naval Medical University Shanghai 200433, China.
- Publication Type:Journal Article
- Keywords:
active components;
effective traditional Chinese medicine;
innovative drug;
therapeutic targets
- MeSH:
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/chemistry*;
Research;
Drug Discovery;
China
- From:
China Journal of Chinese Materia Medica
2023;48(7):1705-1710
- CountryChina
- Language:Chinese
-
Abstract:
Novel drug discovery from the active ingredients of traditional Chinese medicine is the most distinctive feature and advantageous field of China, which has provided an unprecedented opportunity. However, there are still problems such as unclear functional substance basis, action targets and mechanism, which greatly hinder the clinical transformation of active ingredients in traditional Chinese medicine. Based on the analysis of the current status and progress of innovative drug research and development in China, this paper aimed to explore the prospect and difficulties of the development of natural active ingredients from traditional Chinese medicine, and to explore the efficient discovery of trace active ingredients in traditional Chinese medicine, and obtain drug candidates with novel chemical structure, unique target/mechanism and independent intellectual property rights, in order to provide a new strategy and a new model for the development of natural medicine with Chinese characteristics.
