Research progress on chemical structures and pharmacological effects of natural cytisine and its derivatives.
10.19540/j.cnki.cjcmm.20220623.202
- Author:
Qing-Qing ZHOU
1
;
Xiao-Yan XIE
1
;
Yan-Xia ZHANG
2
;
Wu ZHOU
2
;
Zha-Jun ZHAN
3
;
Jin-Biao XU
2
Author Information
1. College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou 310014, China College of Medicine, Jiaxing University Jiaxing 314001, China.
2. College of Medicine, Jiaxing University Jiaxing 314001, China.
3. College of Pharmaceutical Science, Zhejiang University of Technology Hangzhou 310014, China.
- Publication Type:Journal Article
- Keywords:
Fabaceae;
anti-tumor activity;
biosynthesis;
cytisine;
cytisine derivatives;
smoking cessation
- MeSH:
Alkaloids/chemistry*;
Quinolizines/pharmacology*;
Azocines/chemistry*;
Fabaceae
- From:
China Journal of Chinese Materia Medica
2023;48(10):2679-2698
- CountryChina
- Language:Chinese
-
Abstract:
Cytisine derivatives are a group of alkaloids containing the structural core of cytisine, which are mainly distributed in Fabaceae plants with a wide range of pharmacological activities, such as resisting inflammation, tumors, and viruses, and affecting the central nervous system. At present, a total of 193 natural cytisine and its derivatives have been reported, all of which are derived from L-lysine. In this study, natural cytisine derivatives were classified into eight types, namely cytisine type, sparteine type, albine type, angustifoline type, camoensidine type, cytisine-like type, tsukushinamine type, and lupanacosmine type. This study reviewed the research progress on the structures, plant sources, biosynthesis, and pharmacological activities of alkaloids of various types.
