Research progress on chemical constituents and pharmacological effects of Kaixin Powder and predictive analysis of its Q-markers.
10.19540/j.cnki.cjcmm.20220919.201
- Author:
Xuan YANG
1
;
Jun-Ying LI
1
;
Xiao-Xiao SHAN
1
;
Peng HUANG
1
;
Can PENG
1
;
Cai-Yun ZHANG
1
Author Information
1. Anhui Province Key Laboratory of Pharmaceutical Preparation Technology and Application Hefei 230012, China Engineering Technology Research Center of Modernized Pharmaceutics, Anhui Education Department (AUCM) Hefei 230012, China School of Pharmacy, Anhui University of Chinese Medicine Hefei 230012, China Anhui Genuine Chinese Medicinal Materials Quality Improvement Innovation Collaborative Center Hefei 230012, China Institute of Pharmaceutics, Anhui Academy of Chinese Medicine Hefei 230012, China.
- Publication Type:Journal Article
- Keywords:
Kaixin Powder;
Q-marker;
chemical constituent;
pharmacological effect
- MeSH:
Ginsenosides;
Powders;
Drugs, Chinese Herbal/chemistry*;
Medicine, Chinese Traditional
- From:
China Journal of Chinese Materia Medica
2023;48(8):2077-2085
- CountryChina
- Language:Chinese
-
Abstract:
Kaixin Powder is a classic prescription for invigorating Qi, nourishing the mind, and calming the mind. It has pharmacological effects of improving learning and memory ability, resisting oxidation, delaying aging, and promoting the differentiation and regeneration of nerve cells. It is mainly used in the modern clinical treatment of amnesia, depression, dementia, and other diseases. The present paper reviewed the research progress on the chemical composition and pharmacological action of Kaixin Powder, predicted and analyzed its quality markers(Q-markers) according to the concept of Chinese medicine Q-markers, including transmission and traceability, specificity, effectiveness, measurability, and compound compatibility environment. The results suggested that sibiricose A5, sibiricose A6, polygalaxanthone Ⅲ, 3',6-disinapoylsucrose, tenuifoliside A, ginsenoside Rg_1, ginsenoside Re, ginsenoside Rb_1, pachymic acid, β-asarone, and α-asarone could be used as Q-markers of Kaixin Powder. This study is expected to provide a scientific basis for establishing the quality control system and the whole process quality traceability system of Kaixin Powder compound preparations.
