Research summary of chemical constituents and pharmacological effects of Panax notoginseng and predictive analysis on its Q-markers.
10.19540/j.cnki.cjcmm.20230213.201
- Author:
Li-Ping SHI
1
;
Guo-Zhuang ZHANG
1
;
Cong-Sheng LIU
2
;
Zhi-Xin HUANG
2
;
Yu-Qing ZHENG
2
;
Lin-Lin DONG
1
Author Information
1. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences Beijing 100700, China.
2. Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd. Zhangzhou 363000, China.
- Publication Type:Journal Article
- Keywords:
Panax notoginseng;
chemical constituent;
herbal research;
pharmacological action;
quality marker
- MeSH:
Panax notoginseng/chemistry*;
Ginsenosides/analysis*;
Saponins/analysis*;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/pharmacology*;
Panax/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(8):2059-2067
- CountryChina
- Language:Chinese
-
Abstract:
Panax notoginseng contains triterpene saponins, flavonoids, amino acids, polysaccharides, volatile oil and other active components, which have the effects of promoting blood circulation, stopping bleeding, removing blood stasis, etc. This study summarized the herbal research, chemical constituents and main pharmacological activities of P. notoginseng, and based on the theory of Q-markers of traditional Chinese medicine, predicted and analyzed the Q-markers of P. notoginseng from the aspects of plant kinship, efficacy, drug properties, measurability of chemical components, etc. It was found that ginsenosides Rg_1, Re, and Rb_1 with specific content ratio, ginsenosides Rb_2, Rb_3, Rc, Rd, Rh_2, and Rg_3, notoginseng R_1, dencichine and quercetin could be used as potential Q-markers of P. notoginseng, which facilitated the formulation of quality standards reflecting the efficacy of P. notoginseng.
