Research progress on chemical constituents and pharmacological effects of Glechomae Herba and prediction of its Q-markers.
10.19540/j.cnki.cjcmm.20221115.201
- Author:
Qian ZHANG
1
;
Zhu-Zhen HAN
1
;
Li-Hua GU
1
;
Zheng-Tao WANG
1
Author Information
1. MOE Key Laboratory for Standardization of Chinese Medicines, SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine Shanghai 201203, China Shanghai R&D Center for Standardization of Chinese Medicines Shanghai 201203, China.
- Publication Type:Journal Article
- Keywords:
Glechoma longituba;
Glechomae Herba;
chemical constituent;
pharmacological effect;
quality marker
- MeSH:
Apigenin;
Plant Extracts/pharmacology*;
Lamiaceae;
Drugs, Chinese Herbal/pharmacology*;
Flavonoids/pharmacology*
- From:
China Journal of Chinese Materia Medica
2023;48(8):2041-2058
- CountryChina
- Language:Chinese
-
Abstract:
Glechomae Herba, the dried aerial part of Glechoma longituba(Labiatae), has the effects of promoting urination, draining dampness, and relieving stranguria. It has received wide attention in recent years owing to the satisfactory efficacy on lithiasis. Amid the in-depth chemical and pharmacological research, it has been found that Glechomae Herba has antibacterial, anti-inflammatory, antioxidant, antithrombotic, hepatoprotective, cholagogic, antitumor, hypoglycemic, and lipid-lowering effects. The main chemical constituents are volatile oils, flavonoids, terpenoids, phenylpropanoids, and organic acids. This paper summarized the chemical constituents and pharmacological effects of Glechomae Herba. Based on genetic relationship of plants, the characteristics, efficacy, and pharmacokinetics of the chemical constituents, and the potential of these constituents as quality markers(Q-markers), it was summed up that ursolic acid, caffeic acid, rosmarinic acid, luteolin-7-O-diglucuronide, apigenin, apigenin-7-O-diglucuronide, apigetrin, and glechone can be the candidate Q-markers of Glechomae Herba.
