Research progress of histone acetylation in prevention and treatment of heart failure and new ideas based on traditional Chinese medicine.
10.19540/j.cnki.cjcmm.20221115.402
- Author:
Bin WANG
1
;
Lu-Dan ZHANG
1
;
Qi-Fei ZHAO
2
;
Ming-Jun ZHU
2
;
Xin-Lu WANG
2
Author Information
1. Henan University of Chinese Medicine Zhengzhou 450000, China.
2. the First Affiliated Hospital of Henan University of Chinese Medicine Zhengzhou 450000, China.
- Publication Type:Journal Article
- Keywords:
heart failure;
histone acetylation;
mechanism;
traditional Chinese medicine
- MeSH:
Humans;
Medicine, Chinese Traditional;
Histones/therapeutic use*;
Acetylation;
Quality of Life;
Heart Failure/prevention & control*
- From:
China Journal of Chinese Materia Medica
2023;48(8):2010-2019
- CountryChina
- Language:Chinese
-
Abstract:
Chronic heart failure(CHF) has become a worldwide public health problem due to its high morbidity and mortality, which seriously endangers people's lifespan and quality of life. In recent years, the treatment strategy of CHF has shifted its emphasis on short-term improvement and transformation of hemodynamics to long-term repair as well as improvement of the biological properties of heart failure. At present, with the continuous deepening of medical research, it has been found that histone acetylation is closely related to the occurrence and development of CHF. Traditional Chinese medicine, via regulating histone acetylation, delays ventricular remodeling, improves energy metabolism, inhibits fibrosis and cardiomyocyte hypertrophy, and intervenes in the development process of heart failure, thus reducing the mortality and the readmission rate and ultimately improving long-term prognosis. Therefore, this study reviewed the mechanism of histone acetylation in the treatment of heart failure as well as its prevention and treatment with traditional Chinese medicine, to provide reference for clinical treatment of CHF.
