Arsenic speciation and valence.
10.19540/j.cnki.cjcmm.20230213.601
- Author:
Jing LIU
1
;
Ming-Yi SUN
2
;
Hui-Min WU
1
;
Hu-Lin-Yue PENG
1
;
Hua-Ting HUANG
1
;
Ting-Ting FU
1
;
Xiao-Xu DONG
1
;
Xing-Bin YIN
1
;
Chang-Hai QU
1
;
Jian NI
1
Author Information
1. School of Chinese Material Medica, Beijing University of Chinese Medicine Beijing 102488, China.
2. Shanxi Provincial Institute of Traditional Chinese Medicine Taiyuan 030012, China.
- Publication Type:Journal Article
- Keywords:
absorption;
analytical assay;
arsenic;
metabolism;
speciation and valence;
toxicity
- MeSH:
Arsenic/analysis*;
Arsenicals/analysis*;
Sulfides;
Arsenic Trioxide;
Medicine, Chinese Traditional;
Drugs, Chinese Herbal/analysis*;
Biological Products
- From:
China Journal of Chinese Materia Medica
2023;48(9):2396-2405
- CountryChina
- Language:Chinese
-
Abstract:
As arsenic widely exists in nature and has been used in the pharmaceutical preparations, the traditional Chinese medicine(TCM) with arsenic include realgar(As_2S_2 or As_4S_4), orpiment(As_2S_3), and white arsenic(As_2O_3). Among the above representative medicine, the TCM compound formulas with realgar are utilized extensively. Just in Chinese Pharmacopoeia(2020 edition), there are 37 Chinese patent medicines including realgar. The traditional element analysis focuses on the detection of the total amount of elements, which neglects the study on the speciation and valence of elements. The activity, toxicity, bioavailability, and metabolic pathways of arsenic in vivo are closely related to the existence of its form, and different forms of arsenic have different effects on organisms. Therefore, the study on the speciation and valence of arsenic is of great importance for arsenic-containing TCMs and their compound formulas. This paper reviewed four aspects of the speciation and valence of arsenic, including property, absorption and metabolism, toxicity, and analytical assay.
