Structure-activity relationship of Lycium barbarum polysaccharides.
10.19540/j.cnki.cjcmm.20221219.602
- Author:
Xiao-Fei LIANG
1
;
Fang ZHANG
1
;
Yin-Xiu JIANG
1
;
Meng-Qiu LIU
1
;
Sheng GUO
1
;
Da-Wei QIAN
2
;
Jin-Ao DUAN
1
Author Information
1. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Key Laboratory of Chinese Medicinal Resources Recycling Utilization of State Administration of Traditional Chinese Medicine Nanjing 210023, China.
2. Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization, Nanjing University of Chinese Medicine,National and Local Collaborative Engineering Center of Chinese Medicinal Resources Industrialization and Formulae Innovative Medicine, Key Laboratory of Chinese Medicinal Resources Recycling Utilization of State Administration of Traditional Chinese Medicine Nanjing 210023, China Ningxia Gouqi Innovation Center Yinchuan 750002, China.
- Publication Type:Journal Article
- Keywords:
Lycium barbarum;
Lycium barbarum polysaccharides;
biological activity;
functional substance;
molecular structure;
structure-activity relationship
- MeSH:
Lycium/chemistry*;
Drugs, Chinese Herbal/chemistry*;
Structure-Activity Relationship;
Antioxidants/pharmacology*;
Antineoplastic Agents;
Polysaccharides/chemistry*
- From:
China Journal of Chinese Materia Medica
2023;48(9):2387-2395
- CountryChina
- Language:Chinese
-
Abstract:
As a traditional Chinese herb and functional food, the fruits of Lycium barbarum has been widely used for thousands of years in China. L. barbarum polysaccharides(LBPs) are predominant active components, which have immunomodulatory, antioxidant, hypoglycemic, neuroprotective, anti-tumor, and prebiotic activities. The molecular weight, monosaccharide composition, glycosidic bond, branching degree, protein content, chemical modification, and spatial structure of LBPs are closely related to their biological activity. Based on the previous studies of this research team, this paper systematically combed and integrated the research progress of structure, function, and structure-activity relationship of LBPs. At the same time, some problems restricting the clarification of the structure-activity relationship of LBPs were considered and prospected, hoping to provide references for the high value utilization of LBPs and in-depth exploration of their health value.
