Role of macrophages in heart failure and traditional Chinese medicine intervention.
10.19540/j.cnki.cjcmm.20230105.601
- Author:
Kai HUANG
1
;
Dong WANG
1
;
Xue YU
1
;
Jia-Yang TANG
1
;
Jiang YU
1
;
Xiao-Qi WEI
1
;
Hai-Yin PU
1
;
Shu-Zhen GUO
1
Author Information
1. School of Traditional Chinese Medicine, Beijing University of Chinese Medicine Beijing 100029, China.
- Publication Type:Journal Article
- Keywords:
heart failure;
macrophages;
traditional Chinese medicine(TCM)
- MeSH:
Humans;
Medicine, Chinese Traditional;
Heart Failure/drug therapy*;
Macrophages;
Drugs, Chinese Herbal/therapeutic use*
- From:
China Journal of Chinese Materia Medica
2023;48(9):2379-2386
- CountryChina
- Language:Chinese
-
Abstract:
As the disease with high morbidity and mortality in the world, heart failure affects the development of human society. Due to its complicated pathology and limited treatment options, it is urgent to discover new disease targets and develop new treatment strategies. As innate immune cells accompanied by the evolution of heart failure, macrophages play an important role in cardiac homeostasis and stress. In recent years, the role of macrophages in the heart has attracted more and more attention as a potential target for heart failure intervention, and the research on cardiac macrophages has made important progress. Traditional Chinese medicine(TCM) has significant effects on regulating inflammatory response, treating heart failure, and maintaining homeostasis. In this article, researches on the functions of cardiac macrophages and application of TCM were reviewed from the source and classification of cardiac macrophages and the relationship of macrophages and cardiac inflammation, myocardial fibrosis, cardiac angiogenesis, and cardiac electrical conduction, which provided a basis for further basic research and clinical applications.
