Advances in Modeling of Multiple Myeloma in Mice.
10.3881/j.issn.1000-503X.15288
- Author:
Xin-Yuan GU
1
;
Wen-Jiao TANG
1
;
Yan LI
1
;
Li ZHANG
1
;
Yu-Huan ZHENG
1
Author Information
1. Institute of Hematology,Department of Hematology,West China Hospital,Sichuan University,Chengdu 610041,China.
- Publication Type:Journal Article
- Keywords:
model;
mouse;
multiple myeloma
- MeSH:
Humans;
Animals;
Mice;
Multiple Myeloma/pathology*;
Bone Marrow/pathology*;
Disease Models, Animal;
Drug Resistance;
Tumor Microenvironment
- From:
Acta Academiae Medicinae Sinicae
2023;45(3):512-518
- CountryChina
- Language:Chinese
-
Abstract:
Multiple myeloma(MM)is a systemic malignancy of plasma cells.Nowadays,the basic research on MM is flourishing with the continuous optimization and innovation of mouse models of MM.Heterologous mouse models of MM established with human-derived cells and immunodeficient mice have been applied in assessing drug efficacy,exploring drug resistance mechanisms,and observing tumor-bone marrow microenvironment interactions.In the last decades,the homologous mouse models of MM established with murine-derived cells or gene-editing technologies have been widely used in the research on the pathogenesis and drug development.Additionally,the stable modeling of targeted organ injury will be a key problem to be tackled in this field.This review summarizes the characteristics and application progress of mouse models of MM.
