Progressin Tumor-Associated Macrophages in the Treatment of Pancreatic Cancer.
10.3881/j.issn.1000-503X.15282
- Author:
Ke ZHANG
1
;
Ya-Han QIN
1
;
Jie SHEN
1
;
Meng-Yu ZHANG
1
;
Mei-Yu PENG
1
Author Information
1. Key Laboratory of Immune Microenvironment and Inflammatory Disease Research in Universities of shandong Province Immunology Laboratory of Weifang Medical University,Weifang,Shandong 261053,China.
- Publication Type:Journal Article
- Keywords:
immunotherapy;
pancreatic cancer;
targeted therapy;
tumor-associated macrophages
- MeSH:
Humans;
Tumor-Associated Macrophages;
Macrophages;
Pancreatic Neoplasms/pathology*;
Tumor Microenvironment
- From:
Acta Academiae Medicinae Sinicae
2023;45(3):471-478
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatic cancer is one of the digestive system tumors with a high degree of malignancy,and most of the patients are diagnosed in advanced stages.Because of limited available therapies,the mortality of this disease remains high.Tumor-associated macrophages(TAM),the main immune cells in the tumor microenvironment,are involved in the regulation of the occurrence and development of pancreatic cancer.Specifically,TAM are involved in the proliferation,invasion,immune escape,and chemoresistance of pancreatic cancer cells,demonstrating potential in the targeted therapy of pancreatic cancer.In this paper,we summarize the TAM-based therapies including consuming TAM,reprogramming TAM,dynamic imaging of TAM with nanoprobes,and regulating the phagocytic ability of TAM for pancreatic cancer,aiming to provide a theoretical basis for developing new therapies for pancreatic cancer.
