Research Progress in the Role of Tamoxifen in Nervous System and Cognitive Function.
10.3881/j.issn.1000-503X.15035
- Author:
Jin-Nong WANG
1
;
Yi TIAN
1
;
Qing-Yi CAO
1
Author Information
1. Department of Anesthesiology,Haikou Hospital,Xiangya School of Medicine,Central South University,Haikou 570000,China.
- Publication Type:Journal Article
- Keywords:
cognitive dysfunction;
neurological diseases;
neurological function;
protective effect;
tamoxifen
- MeSH:
Tamoxifen/therapeutic use*;
Selective Estrogen Receptor Modulators/therapeutic use*;
Cognition;
Nervous System
- From:
Acta Academiae Medicinae Sinicae
2023;45(2):334-340
- CountryChina
- Language:Chinese
-
Abstract:
Neurological diseases include a variety of neurodegenerative diseases and other brain damage diseases.The treatment schemes for neurological diseases are still in research.The existing clinical and basic studies have confirmed that traditional estrogen therapy has certain protective effect on the nervous system,while it increases the risk of breast or endometrial cancer.The emergence of the selective estrogen receptor modulators (SERMs) can avoid the above mentioned problems.The available studies have confirmed the protective effect of tamoxifen as a SERM on the nervous system.This paper reviews the role and functioning mechanisms of tamoxifen in the nervous system and cognitive function,aiming to provide guidance for the future application of tamoxifen in the treatment of neurological diseases and the improvement of cognitive function.
