Advances in Molecular Targeted Ultrasound Contrast Agents.
10.3881/j.issn.1000-503X.14827
- Author:
Zhen YANG
1
;
Ming-Bo ZHANG
1
;
Yu-Kun LUO
1
Author Information
1. Department of Ultrasound,the First Medical Center of Chinese PLA General Hospital,Beijing 100853,China.
- Publication Type:Journal Article
- Keywords:
diagnosis;
drug delivery;
molecular ultrasound imaging;
targeted contrast agents;
treatment response assessment
- MeSH:
Humans;
Contrast Media/chemistry*;
Molecular Targeted Therapy;
Ultrasonography/methods*;
Diagnostic Imaging
- From:
Acta Academiae Medicinae Sinicae
2023;45(2):298-302
- CountryChina
- Language:Chinese
-
Abstract:
In real-time ultrasound,molecular targeted contrast agent is introduced into the blood circulation through peripheral intravenous injection to enhance the imaging signal of target lesions after binding to the corresponding intravascular receptors,which can realize early diagnosis,staging of diseases,assessment of treatment response,and targeted treatment.In addition,molecular targeted ultrasound contrast agents provide a platform for the delivery of drugs and genes via microbubbles,and nanoscale contrast agents can be infiltrated through vascular endothelium into the interstitial space of the lesion for imaging or treatment.The available studies of molecular targeted ultrasound contrast agents mainly focus on the preclinical trials.Some clinical trials have been conducted in humans and preliminarily confirm the safety and feasibility of targeted ultrasound contrast agents.The molecular targeted ultrasound contrast agents enjoy a broad prospect in clinical application.
