Sentinel Lymph Node Radiolocalization with 99mTc Filtered Tin Colloid in Clinically Node-Negative Squamous Cell Carcinomas of the Oral Cavity.
10.3346/jkms.2006.21.5.865
- Author:
Han Sin JEONG
1
;
Chung Hwan BAEK
;
Young Ik SON
;
Do Yeon CHO
;
Man Ki CHUNG
;
Jin Young MIN
;
Young Hyeh KO
;
Byung Tae KIM
Author Information
1. Department of Otorhinolaryngology-Head and Neck Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea. chbaek@smc.samsung.co kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Sentinel Lymph Node Biopsy;
Lymphatic Metastasis;
Mouth Neoplasms;
Radionuclide Imaging
- MeSH:
Tin Compounds/*diagnostic use;
Technetium Compounds/*diagnostic use;
*Sentinel Lymph Node Biopsy;
Radiopharmaceuticals/*diagnostic use;
Mouth Neoplasms/*pathology/*radionuclide imaging;
Middle Aged;
Male;
Lymphatic Metastasis;
Lymph Nodes/*radionuclide imaging;
Humans;
Female;
Carcinoma, Squamous Cell/*pathology/*radionuclide imaging;
Aged;
Adult
- From:Journal of Korean Medical Science
2006;21(5):865-870
- CountryRepublic of Korea
- Language:English
-
Abstract:
The objective of this study was to evaluate the feasibility of sentinel lymph node biopsy by using a radiotracer lymphatic mapping technique in patients with squamous cell carcinoma of the oral cavity, and the diagnostic value of this technique. We studied twenty patients with previously untreated squamous cell carcinomas of the oral cavity and N0 necks. After the peritumoral injection of 99mTc filtered tin colloid preop-eratively, lymphoscintigraphy and intraoperative mapping using a gamma detector were performed to localize sentinel nodes. An open biopsy of the sentinel node was followed by complete neck dissection. We identified the sentinel nodes in 19 of 20 patients (95.0%) by lymphoscintigraphy and in all (100%) by intraoperative gamma detector. In all cases, the status of the sentinel node accurately predicted the pathologic status of the neck with the false negative rate being 0%. The negative predictive value for the absence of cervical metastases was 100%. In conclusion, our radio-localization technique of sentinel nodes using 99mTc filtered tin colloid in N0 squamous cell carcinomas of the oral cavity is technically feasible and appears to accurately predict the presence of the occult metastatic disease.
