Expression of Cyclooxygenase-2, p53 and Ki-67 in Gastric Cancer.
10.3346/jkms.2006.21.5.871
- Author:
Young Eun JOO
1
;
Ik Joo CHUNG
;
Young Kyu PARK
;
Yang Seok KOH
;
Jae Hyuk LEE
;
Chang Hwan PARK
;
Wan Sik LEE
;
Hyun Soo KIM
;
Sung Kyu CHOI
;
Jong Sun REW
;
Chang Soo PARK
;
Sei Jong KIM
Author Information
1. Gastrointestinal Cancer Research Program, Chonnam National University Medical School, Gwangju, Korea. yejoo@jnu.ac.kr
- Publication Type:Original Article ; Research Support, Non-U.S. Gov't
- Keywords:
Cyclooxygenase 2;
Tumor Suppressor Protein p53;
Cell Proliferation;
Stomach Neoplasms;
Immu-nohistochemistry
- MeSH:
Tumor Suppressor Protein p53/*analysis;
Stomach Neoplasms/*chemistry/mortality/pathology;
Prognosis;
Middle Aged;
Male;
Ki-67 Antigen/*analysis;
Immunohistochemistry;
Humans;
Female;
Cyclooxygenase 2/*analysis;
Aged;
Adult
- From:Journal of Korean Medical Science
2006;21(5):871-876
- CountryRepublic of Korea
- Language:English
-
Abstract:
It has been reported that p53 mutation may contribute to upregulate cyclooxygenase (COX)-2 expression that is observed in malignant tissues. These molecules are involved in carcinogenesis by affecting tumor cell proliferation. The aim of this study was to examine the relationship between COX-2 or p53 expression and clinico-pathological characteristics including tumor cell proliferation in gastric cancer. COX-2 and p53 expressions were investigated with immunostaining, in tissue specimens obtained from 119 patients who underwent surgery for gastric cancer. The Ki-67 labeling index (LI) was counted by Ki-67 immunostaining. COX-2 and p53 expressions correlated significantly with depth of tumor invasion. However, there was no association between COX-2 or p53 expression and survival. p53 expression did not correlate with COX-2 expression. There was no significant difference in various clinicopathological variables between Ki-67 LI subgroups. The mean Ki-67 LI value of COX-2 positive tumors was significantly higher than that of negative tumors. The mean Ki-67 LI value of p53 positive tumors was not significantly higher than that of negative tumors. The mean Ki-67 LI value of both COX-2 and p53 positive tumors was significantly higher than that of both negative tumors. These results imply that COX-2 expression is associated with tumor cell proliferation of gastric cancer.
