Engineering microbial consortia through synthetic biology approach.

Jiao Zhang; Jiangfeng Chen; Yixuan Chen; Lei Dai; Zhuojun Dai

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Engineering microbial consortia through synthetic biology approach.

Author: Jiao ZHANG ¹ ; Jiangfeng CHEN ¹ ; Yixuan CHEN ¹ ; Lei DAI ¹ ; Zhuojun DAI ¹
Author Information

1. Institute of Synthetic Biology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, Guangdong, China.
Publication Type:Journal Article
Keywords: communication; division of labor; synthetic biology; synthetic microbial consortia
MeSH: Microbial Consortia/genetics*; Synthetic Biology; Microbiota; Models, Theoretical
From: Chinese Journal of Biotechnology 2023;39(5):2517-2545
CountryChina
Language:Chinese
Abstract: There are a large number of natural microbial communities in nature. Different populations inside the consortia expand the performance boundary of a single microbial population through communication and division of labor, reducing the overall metabolic burden and increasing the environmental adaptability. Based on engineering principles, synthetic biology designs or modifies basic functional components, gene circuits, and chassis cells to purposefully reprogram the operational processes of the living cells, achieving rich and controllable biological functions. Introducing this engineering design principle to obtain structurally well-defined synthetic microbial communities can provide ideas for theoretical studies and shed light on versatile applications. This review discussed recent progresses on synthetic microbial consortia with regard to design principles, construction methods and applications, and prospected future perspectives.