Advances in biotransformation of methanol into chemicals.

Kang Liu; Yangyi Qiao; Shangjie Zhang; Feng Guo; Jiangfeng MA; Fengxue Xin; Wenming Zhang; Min Jiang

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Advances in biotransformation of methanol into chemicals.

Author: Kang LIU ¹ ; Yangyi QIAO ¹ ; Shangjie ZHANG ¹ ; Feng GUO ¹ ; Jiangfeng MA ¹ ; Fengxue XIN ¹ ; Wenming ZHANG ¹ ; Min JIANG ¹
Author Information

1. State Key Laboratory of Materials-oriented Chemical Engineering, College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 210000, Jiangsu, China.
Publication Type:Journal Article
Keywords: bio-based chemicals; bioconversion of methanol; natural methylotrophs; synthetic methylotrophs
MeSH: Humans; Methanol/metabolism*; Metabolic Engineering; Metabolic Networks and Pathways; Biotransformation
From: Chinese Journal of Biotechnology 2023;39(6):2430-2448
CountryChina
Language:Chinese
Abstract: Methanol has become an attractive substrate for the biomanufacturing industry due to its abundant supply and low cost. The biotransformation of methanol to value-added chemicals using microbial cell factories has the advantages of green process, mild conditions and diversified products. These advantages may expand the product chain based on methanol and alleviate the current problem of biomanufacturing, which is competing with people for food. Elucidating the pathways involving methanol oxidation, formaldehyde assimilation and dissimilation in different natural methylotrophs is essential for subsequent genetic engineering modification, and is more conducive to the construction of novel non-natural methylotrophs. This review discusses the current status of research on methanol metabolic pathways in methylotrophs, and presents recent advances and challenges in natural and synthetic methylotrophs and their applications in methanol bioconversion.